Posts

The Wolbachia Holy Grail: loci behind CI

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This obscure alpha-proteobacterium, named Wolbachia , was first discovered because of the weird ways in which it messed with insect reproduction - everything from parthenogenesis induction to male killing to the most common of effects, so-called "cytoplasmic incompatibility." In this case, Wolbachia somehow prevents uninfected females and infected males from mating. Ever since it was first described by Hertig and Wolbach back in 1924, folks have been trying to figure out the how of CI.  At the Wolbachia 2016 meetings, it seems like someone(s) has finally cracked that nut.  <DISCLAIMER: I am actually sitting on my ass in my home office and not at the #Wolb2016 meetings as they are in Australia and I'm allergic to traveling to Australia. However, I heard on the twitter that> Seth Bordenstein + Daniel LePage and John Beckman presented data on two loci - WD0631 and WD0632 - which  may be behind CI. It seems like these loci, when co-expressed in an uninfected male ...

Learning to fly, with microbes

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It's summer and that means time for research and reading groups here at IU Bloomington.  Given the interest in Drosophila across the department, I thought it might be fun to start a fly microbiome reading group this summer. We've got a really dynamic and diverse group -- everyone from stock center folks to genomics gurus and graduate students working in flies.  If you're already working in the fly, and haven't thought about the effect of the microbial community - shame on you!; seriously, have you had your head in a hole for the last decade? Beyond ignoring Wolbachia infection and effects on host phenotypes (such as i nsulin signaling , oogenesis , and others), ignoring the entire microbial community is really not defendable any more.  If you haven't been interested in the fly microbiome, because it's depauperate (what a nasty word, aye?) and generally inconstant,  I hope to change your mind. Here are some of the papers we've been reading lately: ...